SOURCES OF GAMMA-EMITTING RADIONUCLIDES IN THE PRODUCTION OF RADIOPHARMACEUTICALS USING ТНЕ CYCLONE 18/9 HC CYCLOTRON

D. Brinkevich, S. Brinkevich, H. Kiyavitskaya, A. Kiyko
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Abstract

The accumulation of secondary radionuclides (PRN) in water [18O]H2O under irradiation on a Cyclone 18/9 HC cyclotron with a niobium target and an entrance window made of Havar alloy was studied. It is shown that the activity of PRN is mainly determined by the accumulated dose of the target. The dominant source of PRN is the entrance window made of Havar alloy. The niobium target is the source of only one radionuclide, 92mNb, whose activity is low. In the process of water activation, radioisotopes 7Be and probably 65Zn are formed. The water [18O] H2O irradiated on the cyclotron is a dispersed system. Up to 30 % of the activity of cobalt and manganese, as well as ~7% of chromium, are in the composition of solid particles >5 microns in size, washed out of the input foil of the cyclotron target due to intergranular corrosion.
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使用ТНЕ旋风18/ 9hc回旋加速器生产放射性药物中的γ -发射放射性核素来源
研究了以铌为靶材,以Havar合金为入口窗的Cyclone 18/9 HC回旋加速器辐照下水[18O]H2O中次生放射性核素(PRN)的积累。结果表明,PRN的活性主要取决于靶体的累积剂量。PRN的主要来源是由Havar合金制成的入口窗。铌靶是唯一一种放射性核素92mNb的来源,其活性很低。在水活化过程中,形成放射性同位素7Be,可能还有65Zn。在回旋加速器上辐照的水[18O] H2O是一个分散体系。高达30%的活性钴和锰,以及~7%的活性铬,是由尺寸>5微米的固体颗粒组成的,由于晶间腐蚀从回旋加速器靶的输入箔中冲洗出来。
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