Peripheral Artery Stenosis Detection by Wavelet Coherence Analysis

Abstract

Peripheral arterial disease (PAD) is a pandemic affecting over 200 million patients facing a high risk of cardiovascular morbidity and mortality. Primary PAD evaluation and screening are performed by calculating the ankle to upper-arm (brachial) systolic pressure ratio (ABI) despite its severe limitations. Novel modality and indices are presented for non-invasive monitoring of extremity perfusion, which employs miniature-sensors and impedance electrodes. Our novel indices of the peripheral perfusion wave dynamics were derived in the time-frequency domain over hundreds of cardiac cycles. The novel modality detected cuff compression induced arterial-stenosis, even with clinically intact ABI (pressure).