Hypernoradrenergic innervation and vascular smooth muscle hyperplastic change.

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158858
R J Head
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引用次数: 47

Abstract

Two distinguishing features of the vasculature of the spontaneously hypertensive rat (SHR) are an increased sympathetic innervation and vascular smooth muscle hyperplasia. Evidence supporting the existence of hypernoradrenergic innervation and vascular smooth muscle cell hyperplasia is presented with emphasis upon the possible interrelationships between the two events. The results of experiments designed to explore this relationship are presented and include the determination of the role of endogenous nerve growth factor (NGF) and the influence of exogenous NGF on the development of sympathetic innervation of blood vessels and blood pressure change. Attention is focused upon elevated levels of 3-methylhistidine (a biochemical marker for contractile proteins) in the mesenteric vasculature of the SHR. The potential relationships between hypernoradrenergic innervation and increased concentrations of 3-methylhistidine are explored.
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高去甲肾上腺素能神经支配与血管平滑肌增生性改变。
自发性高血压大鼠(SHR)的两个显著特征是交感神经支配增加和血管平滑肌增生。证据支持高去甲肾上腺素能神经支配和血管平滑肌细胞增生的存在,并强调两者之间可能的相互关系。本文介绍了旨在探讨这种关系的实验结果,包括内源性神经生长因子(NGF)作用的测定以及外源性神经生长因子对血管交感神经支配发育和血压变化的影响。注意力集中在SHR肠系膜血管中3-甲基组氨酸(一种可收缩蛋白的生化标记物)水平升高。高去甲肾上腺素能神经支配和3-甲基组氨酸浓度增加之间的潜在关系进行了探讨。
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