Heterogeneity of capillary perfusion.

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158862
P Gaehtgens
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引用次数: 9

Abstract

Heterogeneity represents a general feature of capillary networks. All of the parameters which describe hemodynamic, geometric or functional aspects of such networks exhibit considerable spatial dispersion. This is to some extent the result of the morphological and topological design of the network, reinforced by the nonhomogeneous nature of the flowing blood. Temporal dispersions are introduced by smooth muscle activity, which may be rhythmic or just oscillatory, but also by the passage of white cells causing transient perturbations. The functional relevance of perfusion heterogeneity follows from its effect on exchange efficiency. While evidence for the existence of physiological control mechanisms of heterogeneity is uncertain, intranetwork communication between upstream and downstream vessel segments appears to support the adaptation of supply to demand under physiological conditions.

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毛细血管灌注的异质性。
非均质性是毛细管网络的一个普遍特征。描述这种网络的血流动力学、几何或功能方面的所有参数都表现出相当大的空间分散。这在某种程度上是网络的形态和拓扑设计的结果,流动的血液的非均匀性加强了这一点。时间色散是由平滑肌活动引起的,这可能是有节奏的或只是振荡的,但也可能是由白细胞的通过引起的短暂扰动引起的。灌注异质性的功能相关性来源于其对交换效率的影响。尽管存在异质性生理控制机制的证据尚不确定,但上游和下游血管段之间的网络内通信似乎支持生理条件下供需的适应。
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