Role of the local renin-angiotensin system in the autoregulation of the cerebral circulation.

Blood vessels Pub Date : 1991-01-01 DOI:10.1159/000158867
O B Paulson, G Waldemar
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引用次数: 36

Abstract

Inhibition of angiotensin-converting enzyme (ACE) shifts the limits of cerebral blood flow autoregulation toward lower blood pressure values. This effect seems to be mediated by blocking the formation of angiotensin II on the luminal side of the larger cerebral resistance vessels. Baseline cerebral blood flow (the flow within the autoregulatory limits) is not changed by acute or chronic ACE inhibition. An interaction between the vascular reninangiotensin and the sympathetic nervous system is present. Activation of the latter inhibits the downwards shift of the upper limit of autoregulation following ACE inhibition.

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局部肾素-血管紧张素系统在脑循环自动调节中的作用。
抑制血管紧张素转换酶(ACE)将脑血流自动调节的极限转向降低血压值。这种作用似乎是通过阻断大脑血管管腔侧血管紧张素II的形成而介导的。急性或慢性ACE抑制不改变基线脑血流量(在自身调节限度内的流量)。血管肾素血管紧张素与交感神经系统之间存在相互作用。后者的激活抑制了ACE抑制后自调节上限的下移。
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