Immune System Response to Weight Loss among Obese Saudi Non-Alcoholic Fatty Liver Disease Subjects

Abstract

Globally, non-alcoholic fatty liver disease (NAFLD) considered as a common chronic liver disorder [1]. Similarly, about 30% of European people have NAFLD [2]. Moreover, about 2550% of worldwide people have NAFLD which is the major cause of abnormal liver enzymes [3]. There is an association between NAFLD and obesity [4]. Abnormal immunological and systemic inflammation parameters are the key for NAFLD pathogenesis [5-8]. However, abnormal immune system performance not only induce NAFLD but also contributes progression and NAFLD associated disorders [9-11]. In addition, obesity is usually associated with abnormal immunological parameters values [12]. Altered immune system competence is usually a common finding associated with obesity subjects and the level of deterioration in immune system performance is related to obesity grade [13]. Similarly, about 30% of some malignant tumors are associated with obesity [14]. Many researchers reported abnormal values of immune system parameters among obese individuals [15-17].