Hanan Moussa, MSc, Wenge Jiang, Ammar A. Alsheghri, A. Mansour, A. E. Hadad, H. Pan, R. Tang, Jun Song, J. Vargas, M. McKee, F. Tamimi
{"title":"High Strength Brushite Bioceramics by Selective Regulation with Chiral Biomolecules","authors":"Hanan Moussa, MSc, Wenge Jiang, Ammar A. Alsheghri, A. Mansour, A. E. Hadad, H. Pan, R. Tang, Jun Song, J. Vargas, M. McKee, F. Tamimi","doi":"10.2139/ssrn.3455086","DOIUrl":null,"url":null,"abstract":"In biomineralization, biological molecules guide the formation and organization of inorganic crystals to construct materials that have exceptional mechanical properties. In Nature, these biomolecules are homochiral, composed exclusively of L-amino acids. Here, we show that chiral tartaric acid can improve the mechanical properties of a calcium-phosphate bioceramic by regulating its crystal structure. The mechanical properties of brushite bioceramic were improved by the addition of L-(+)-tartaric acid, which decreased crystal size, with this relationship following the classic Hall-Petch strengthening effect; D-(-)-tartaric acid had the opposite effect. Characterization of brushite crystals from the macro- to the atomic-level revealed that this regulation is attributable to a stereochemical matching between L-(+)-tartaric acid and chiral steps of brushite crystals, which results in inhibition of brushite crystallization. These findings provide insight into understanding the role of chiral L-biomolecules in biomineralization, and how bioceramics can be fabricated with a controlled crystallographic structure that defines high-performance mechanical properties.","PeriodicalId":105746,"journal":{"name":"AMI: Acta Biomaterialia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"AMI: Acta Biomaterialia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2139/ssrn.3455086","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
In biomineralization, biological molecules guide the formation and organization of inorganic crystals to construct materials that have exceptional mechanical properties. In Nature, these biomolecules are homochiral, composed exclusively of L-amino acids. Here, we show that chiral tartaric acid can improve the mechanical properties of a calcium-phosphate bioceramic by regulating its crystal structure. The mechanical properties of brushite bioceramic were improved by the addition of L-(+)-tartaric acid, which decreased crystal size, with this relationship following the classic Hall-Petch strengthening effect; D-(-)-tartaric acid had the opposite effect. Characterization of brushite crystals from the macro- to the atomic-level revealed that this regulation is attributable to a stereochemical matching between L-(+)-tartaric acid and chiral steps of brushite crystals, which results in inhibition of brushite crystallization. These findings provide insight into understanding the role of chiral L-biomolecules in biomineralization, and how bioceramics can be fabricated with a controlled crystallographic structure that defines high-performance mechanical properties.