A comprehensive (biological and computational) investigation on the role of microRNA::mRNA regulations performed in chronic obstructive pulmonary disease and lung cancer

2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) Pub Date : 2016-12-01 DOI:10.1109/BIBM.2016.7822669

Jingshan Huang, D. Dou, Jun She, A. Limper, Yanan Yang, Ping Yang

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引用次数: 4

Abstract

Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are two serious diseases that present a major health problem worldwide. However, genetic contribution to both diseases remains unclear, including various regulation mechanisms at genetic level resulting in the progression from COPD to LC. In this paper, we describe our comprehensive methodologies, which seamlessly integrate both biological (conducted in “wet labs”) and computational (based on domain ontologies and semantic technologies) approaches, to investigate the important role of microRNA::mRNA regulations performed in COPD and LC. We discovered two genes, RGS6 and PARK2, that are strongly associated with the risk of developing either COPD or LC or both; additionally, we also identified two sets of microRNAs that are computationally predicted to regulate RGS6 and PARK2, respectively. These microRNAs can be further biologically verified in the future and serve as novel biomarkers in COPD and/or LC.

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对microRNA::mRNA调控在慢性阻塞性肺病和肺癌中的作用进行了全面的(生物学和计算)研究

慢性阻塞性肺疾病(COPD)和肺癌(LC)是两种严重的疾病，是世界范围内的主要健康问题。然而，遗传对这两种疾病的影响尚不清楚，包括遗传水平上导致从COPD到LC进展的各种调节机制。在本文中，我们描述了我们的综合方法，该方法无缝集成了生物学(在“湿实验室”中进行)和计算(基于领域本体和语义技术)方法，以研究microRNA::mRNA调控在COPD和LC中发挥的重要作用。我们发现了两个基因，RGS6和PARK2，它们与患COPD或LC或两者的风险密切相关;此外，我们还鉴定了两组计算预测分别调节RGS6和PARK2的microrna。这些microrna可以在未来进一步进行生物学验证，并作为COPD和/或LC的新型生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

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