Jhih-Ying Chen, Chia-Min Chen, Pei-Chun Chang, J. Tsai
{"title":"The Potential Dual-Target Inhibitors for HER2/HSP90 Proteins from Traditional Chinese Medicine","authors":"Jhih-Ying Chen, Chia-Min Chen, Pei-Chun Chang, J. Tsai","doi":"10.1109/BIBE.2018.00061","DOIUrl":null,"url":null,"abstract":"Cancer is a fatal disease. It is worth noting that the treatment of cancer still lacks effective drugs for cancer resistance. The development of multi-target drugs is an important direction in the future. Human epidermal growth factor receptor (EGFR and HER2) and Heat shock protein 90 (HSP90) have been proven to be useful targets in various cancer cell lines. To develop dual-target drugs for these two proteins may be more effective in cancer treatment. We performed ligand-based QSAR modeling to select potential TCM candidate compounds for HER2/HSP90 inhibition. The results show that cyclokoreanine B, dehydropodophyllotoxin, alloimperatorine, wanpeinine A, zierin, N-demethylnoracronycine, desacetyleupaserrin, dianthramine, gnoscopine, and formononetin might have the potential for HER2/HSP90 inhibition.","PeriodicalId":127507,"journal":{"name":"2018 IEEE 18th International Conference on Bioinformatics and Bioengineering (BIBE)","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"2018 IEEE 18th International Conference on Bioinformatics and Bioengineering (BIBE)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/BIBE.2018.00061","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Cancer is a fatal disease. It is worth noting that the treatment of cancer still lacks effective drugs for cancer resistance. The development of multi-target drugs is an important direction in the future. Human epidermal growth factor receptor (EGFR and HER2) and Heat shock protein 90 (HSP90) have been proven to be useful targets in various cancer cell lines. To develop dual-target drugs for these two proteins may be more effective in cancer treatment. We performed ligand-based QSAR modeling to select potential TCM candidate compounds for HER2/HSP90 inhibition. The results show that cyclokoreanine B, dehydropodophyllotoxin, alloimperatorine, wanpeinine A, zierin, N-demethylnoracronycine, desacetyleupaserrin, dianthramine, gnoscopine, and formononetin might have the potential for HER2/HSP90 inhibition.
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