The Relation between Vitamin D Level and Pregnancy Outcome in Women with Unexplained Infertility Undergoing Induction of Ovulation

Abstract

Objective: assess the association between serum level of Vitamin D and pregnancy outcome in women with unexplained infertility undergoing an induction of ovulation. Methods: cohort study including women with unexplained infertility .Results: the vitamin D level was significantly higher in pregnant women than non pregnant. After adjustment for the effect of other variables, there was no statistically significant relation between vitamin D level and chemical pregnancy. On the other hand, secondary infertility was an independent predictor of chemical pregnancy. Our results showed that vitamin D level has limited predictive value with an area under the ROC curve (AUC) of 0.621. The best cutoff is a value of >32.5 ng/mL, which has a sensitivity of 28% and specificity of 95%. There is weak negative correlation between serum vitamin D and LH level. Lastly, after adjustment for the effect of other variables, adequate vitamin D and secondary infertility were an independent predictors of chemical pregnancy. There was significantly high rate of positive chemical pregnancy test among women had sufficient serum vitamin D when compared to those had deficient/ insufficient serum vitamin D.Conclusion: There was no statistically significant relation between vitamin D level and pregnancy outcome in women with unexplained infertility undergoing induction of ovulation. Moreover, our results showed that vitamin D level has limited predictive value in women with unexplained infertility undergoing induction of ovulation, the best cutoff value was >32.5 ng/mL. After adjustment for the effect of other variables, adequate vitamin D was an independent predictors of chemical pregnancy.