Piotr Roszkowski , Stefan Czarnocki , Jan K. Maurin , Aleksandra Siwicka , Anna Zawadzka , Joanna Szawkało , Andrzej Leniewski , Zbigniew Czarnocki
{"title":"Variety of natural products derived from tryptophan and stereoselective synthesis of tetrahydro-β-carboline derivatives of pharmacological importance","authors":"Piotr Roszkowski , Stefan Czarnocki , Jan K. Maurin , Aleksandra Siwicka , Anna Zawadzka , Joanna Szawkało , Andrzej Leniewski , Zbigniew Czarnocki","doi":"10.1016/j.ics.2007.07.003","DOIUrl":null,"url":null,"abstract":"<div><p>The use of chiral inductors belonging to different classes of compounds is elaborated. Tetrahydro-β-carboline derivatives were constructed stereoselectively by the use of (<em>R</em>)-1-arylethylamine and <span>l</span>-amino acids. Asymmetric transfer hydrogenation was proven highly effective in enantioselective synthesis of several alkaloids.</p></div>","PeriodicalId":84918,"journal":{"name":"International congress series","volume":"1304 ","pages":"Pages 46-59"},"PeriodicalIF":0.0000,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ics.2007.07.003","citationCount":"8","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International congress series","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0531513107004104","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 8
Abstract
The use of chiral inductors belonging to different classes of compounds is elaborated. Tetrahydro-β-carboline derivatives were constructed stereoselectively by the use of (R)-1-arylethylamine and l-amino acids. Asymmetric transfer hydrogenation was proven highly effective in enantioselective synthesis of several alkaloids.
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