Adolescente com alto risco para Psicose (“Ultra High Risk”): uma revisão integrativa

Karina Mayumi Kawakami, Sonia Maria Motta Palma Sonia Maria Motta Palma, Rayssa Nailla Santos Duarte, Heloisa Rocha Falcão, B. Modesto
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Abstract

OBJECTIVE: Many psychotic disorders such as schizophrenia can start with attenuated psychotic symptoms and / or declining social and occupational functions. People who present with these “prodromal” characteristics are described as being at Ultra High Risk (UHR) for psychosis. Due to the impact that these disorders have on their quality of life, it is important to review the existing literature. The aim was to conduct an integrative review on UHR and its impact on the quality of life in children and adolescents. METHODS: Searched for articles in the Pubmed database in the period 2010-2019 with the following descriptors: "Psychotic Disorders", "Risk Factors", "Schizophrenia", "Clinical Diagnosis". RESULTS: The search selected 10 articles and an Australian guideline Orygen, of which seven were selected for the present review after analysis. According to the results found, several psychotic disorders may have prodromal characteristics that are the same as Ultra High Risk (UHR). CONCLUSION: Patients with psychosis have worsened quality of life and more unfavorable prognosis, therefore, UHR present an opportunity for intervention to prevent the onset of the first psychotic episode. In clinical trials conducted with UHR patients, both the duration and periods of intervention have been relatively short. Thus, the question remains whether this intervention in the productive phase is effective over time. There should be more discussion about the cost benefit of treatments in UHR patients.
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精神病高危青少年(“超高风险”):一项综合综述
目的:许多精神障碍如精神分裂症可以精神病症状减轻和/或社会和职业功能下降开始。表现出这些“前驱”特征的人被描述为精神病的超高风险(UHR)。由于这些疾病对其生活质量的影响,回顾现有文献是很重要的。目的是对UHR及其对儿童和青少年生活质量的影响进行综合审查。方法:在Pubmed数据库中检索2010-2019年期间描述词为“精神障碍”、“危险因素”、“精神分裂症”、“临床诊断”的文章。结果:检索到10篇文章和一篇澳大利亚指南Orygen,经分析后从中选出7篇纳入本综述。根据结果发现,一些精神障碍可能具有与超高风险(UHR)相同的前驱特征。结论:精神病患者生活质量较差,预后较差,因此,UHR为预防首次精神病发作的干预提供了机会。在对UHR患者进行的临床试验中,干预的持续时间和时间都相对较短。因此,问题仍然是这种在生产阶段的干预是否随着时间的推移而有效。应该对UHR患者治疗的成本效益进行更多的讨论。
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