Effect of Prednicarbate On the Hyper Proliferation of the Granulation Tissue of Traumatic Wounds During Directed Healing: A Prospective Observational Study

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Abstract

Background: The directed scarring of traumatic wounds in a surgical department often encounters drifts. During the proliferation phase, the granulation tissue can become excessive, blocking re-epithelialization and dooming a skin graft. To cope with this, healthcare teams often use topical corticosteroids such as Prednicarbate which is a nonhalogenated corticosteroid which does not pass into the systemic circulation. Purpose: The aim of this study is to describe the in vivo effect of Prednicarbate on the hyper proliferation of granulation tissue in trauma wounds and burns during directed scarring. Methods: A prospective observational study was carried out on patients admitted consecutively to the Orthopaedic and Trauma Surgery Department of Aristide le Dantec Hospital in Dakar. The application of 0.25% prednicarbate was twice daily on the hyperprofiltration areas of the wound bed of consenting patients. Demographic, clinical, therapeutic data and changes in granulation tissue were collected. Results: 12 patients participated with an average age 41.5 ± 18.94 years and a female to male sex ratio of 3/1. Domestic accidents were the most common wound occurrence in 7 cases. After at least 3 applications, the modifications observed were as follows: the proportion of hyper-budding surface was reduced by 3% on average. In 8 cases, the bed turned pink, with a texture changing from smooth to granite in 10 cases. A regression of the edema of the bed was observed in all the cases and the level of the bed of the wound which initially known epidermal, became epidermal in 10 cases. In 10 cases, the start of epidermal migration was observed from the skin edges. In 9 cases, or 75% of cases, it took just 1 tube to see a reduction in granulation tissue. Conclusion: Prednicarbate is a non-halogenated corticosteroid which is of interest in reducing the excessive proliferation of granulation tissue in traumatic wounds. By normalizing the level of granulation tissue, it promotes epidermal migration and the epithelialization phase.
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prenicarbate对创伤性伤口定向愈合过程中肉芽组织过度增殖的影响:一项前瞻性观察研究
背景:外伤性伤口的定向瘢痕形成在外科经常遇到漂移。在增殖阶段,肉芽组织可以变得过多,阻碍再上皮化和注定的皮肤移植。为了解决这个问题,医疗团队经常使用局部皮质类固醇,如Prednicarbate,这是一种不进入体循环的非卤化皮质类固醇。目的:本研究的目的是描述Prednicarbate对创伤伤口和烧伤定向瘢痕过程中肉芽组织过度增殖的体内影响。方法:对达喀尔Aristide le Dantec医院骨科和创伤外科连续收治的患者进行前瞻性观察研究。同意患者伤口床高渗区每日2次应用0.25%泼尼甲酸酯。收集人口统计学、临床、治疗数据及肉芽组织变化。结果:12例患者参与,平均年龄41.5±18.94岁,男女性别比为3/1。7例中以家庭意外伤为主。至少施用3次后,观察到的变化如下:超出芽表面的比例平均降低了3%。8个案例中,床变成了粉红色,10个案例中,床的质地从光滑变为花岗岩。所有病例均观察到床层水肿消退,10例伤口床层由最初的表皮层变为表皮层。在10例中,表皮迁移从皮肤边缘开始。在9个病例中,即75%的病例中,只需要1根试管就可以看到肉芽组织的减少。结论:泼尼碳酸酯是一种非卤化皮质类固醇,对减少创伤创面肉芽组织过度增生有重要作用。通过使肉芽组织水平正常化,它促进表皮迁移和上皮化阶段。
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