Rosin and rosin derivatives as hydrophobic matrix materials for controlled release of drugs.

Drug design and delivery Pub Date : 1990-09-01
Y V Pathak, A K Dorle
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Abstract

The evaluation of rosin, a rosin hard paraffin adduct, and four rosin esters as hydrophobic matrix materials for the controlled release of drugs is reported, using aspirin as a drug model. Aspirin matrix tablets were prepared using a wet granulation (nonaqueous) method, and were evaluated for various pharmaceutical parameters. Dissolution studies in pH 7.2 phosphate buffer showed that all formulations had hardness greater than 6 kg/cm2 and disintegration time greater than 150 min. Release of aspirin from the formulations obeyed a diffusion controlled first order kinetic and linear to the square root of time function. Two of the resin ester formulations had a T80% of more than 4 hr. The results suggest that these esters may find application in the development of sustained release formulations for the local treatment of dental diseases, or--as tablet matrices suitably coated with acid resistant material--in the development of oral sustained release drug delivery systems.

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松香及其衍生物作为药物控释的疏水性基质材料。
本文以阿司匹林为药物模型,对松香、一种松香硬石蜡加合物和四种松香酯作为药物控释的疏水基质材料进行了评价。采用湿造粒(非水)法制备阿司匹林基质片,并对其各项药物参数进行了评价。在pH为7.2的磷酸盐缓冲液中溶出实验表明,所有制剂的硬度均大于6 kg/cm2,崩解时间均大于150 min。阿司匹林的释放服从扩散控制的一级动力学,与时间的平方根呈线性关系。两种树脂酯配方的T80%大于4小时。结果表明,这些酯可以应用于口腔疾病局部治疗的缓释制剂的开发,或作为片剂基质,适当地涂覆耐酸材料,用于口服缓释药物输送系统的开发。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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