New Vitamin E Analogues

Abstract

Lipid peroxidation is the mediator of several pathophysiological events such atherosclerosis, neurodegenerative disease and others. It is induced by reactive oxygen species that react with biological substrates, leading to cell damage. It is thought that Nicotinamide Adenine Dinucleotide Phosphate Hydrogen oxidases, as well as mitochondria dysfunction and other sources, are at the centre of these events, so it becomes an important therapeutic target. In order to retard this damage and the progression of the disease, the natural and synthetic antioxidant vitamin E (Tocopherol) has been studied extensively. In this study, we briefly address current knowledge on the function of vitamin E and try to emphasize its antioxidant properties versus its other properties. The purpose of this study is to design and synthesize a new vitamin E analogue that is placed outside cells. The precursor to a new vitamin E analogue bearing two charges is prepared from the reaction of the corresponding (6acetoxy-2,5,7,8- tetramethylchroman-2-yl) acyl chloride compound that was directly treated with an aniline-2,5-disulfonic acid tetrabutylammonium salt. The latter, a newly prepared compound, is considered a target. The new tocopherol analogue of the product was expected to exhibit protection of lipid membrane from the oxidative damage behavior of reactive oxygen species.