Magnetically Targeted Drug Delivery System through Imaging Technology PID Feedback Control and MATLAB

Faizan Saifullah, H. Inam, M. Ali, Umar Ansari
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Abstract

Conventional dose such as capsules which are used traditionally have severe side effects including raising of blood sugar level by dissolution of drug in blood, can be overcome by replacing traditional drug delivery with specifically targeted drug delivery system. The main concept of using magnetic levitation for drug delivery is to deliver the drug to a specific point via magnetic actuation and imaging technique, magnetic material encoated by drug can rupture the artery by getting strongly attracted towards externally applied magnetic field. By taking magnetically levitated drug to the targeted area, it will minimize the risk of rupturing of the artery. Dispersion of drug will be minimized as drug-coated core will be under influence of applied electromagnetic field, drug can be released by altering electromagnetic fields. In this study, one-dimensional (1D) force system is used. Two forces counter each other i.e. electromagnetic force and gravitational force. Addition of Ki to Kp and Kd speeds up the motion when reaching to the targeted set point, blob stays in levitated condition around the set point thus stability is increased by the addition of Ki but oscillation are still present that hinders the stability of the system. Exponential function is introduced to decrease the power of Kp, in result, it supplies the power when the error is large, power gets zero when error is reduced to zero. In this stable system, Kp and Kd gain are applied to minimize the oscillations and keep the blob levitated at targeted set point.
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基于成像技术、PID反馈控制和MATLAB的磁靶向给药系统
传统上使用的胶囊等常规剂量具有严重的副作用,包括药物在血液中溶解导致血糖水平升高,可以通过用特异性靶向药物传递系统取代传统的药物传递来克服。利用磁悬浮给药的主要概念是通过磁致动和成像技术将药物递送到特定的点,药物包裹的磁性材料受到外界磁场的强烈吸引,可以使动脉破裂。通过将磁悬浮药物带到目标区域,可以将动脉破裂的风险降至最低。由于药包芯受到外加电磁场的影响,使药物的分散最小化,改变电磁场可使药物释放。本研究采用一维(1D)力系统。两种力相互抵消,即电磁力和重力。在Kp和Kd中加入Ki加速了运动,当达到目标设定点时,blob在设定点周围保持悬浮状态,因此通过添加Ki增加了稳定性,但仍然存在振荡,阻碍了系统的稳定性。引入指数函数降低Kp的功率,在误差较大时提供功率,误差减小到零时功率为零。在这个稳定的系统中,Kp和Kd增益被应用于最小化振荡并使斑点悬浮在目标设定点。
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