33rd International Meeting of the German Society for Cardiovascular Engineering

Abstract

. Methods: We investigated in 10 patients undergoing off-pump coronary revascularization intra-and postoperatively the change in markers of contact activation (FXII, C3a), coagulation (FXIII, Fab 1/2), inflammatory response (elastase, IL-6, procalcitonin), astroglial damage (S-100b, MMST), and myocardial ischemia (CK, CK-MB, TropT) and compared the data with 10 on-pump CABG patients. Results: Most interestingly we found no group differences in FXII, which plays a major role in contact activation after exposition of blood to foreign surfaces of the extracorporeal circuit. C3a as representative of the alternative pathway of complement activation showed only weak statistical difference. Coagulation and cerebral markers remained nearly unaffected with at least a more concise increase of Fab 1/2 after on-pump surgery. Inflammatory response could not be detected by IL-6