[Requirements for standards for monoclonal anti-A and anti-B antibodies].

Ceskoslovenska farmacie Pub Date : 1990-11-01
A Májský
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Abstract

On the model of the Soviet monoclonal anti-A and anti-B antibody--erythrocytes of the groups A1, A2, A1B and A2B the conditions for the elaboration of the branch standard for anti-A and anti-B monoclonal antibodies were worked out. In comparison with the standard for human sera determining the ABO groups, the requirement for avidity can be increased, furthermore it seems necessary to determine the percentage of non-A blood cells in the A2B group, which should not exceed 30%, and the percentage of non-B blood cells in A1B erythrocytes, which should not exceed 10%.

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【单克隆抗a、抗b抗体标准品要求】。
以苏联单克隆抗a和抗b抗体——A1、A2、A1B和A2B组红细胞为模型,制定了抗a和抗b单克隆抗体分支标准的条件。与测定ABO血型的人血清标准相比,对血清学的要求可以提高,而且似乎有必要测定A2B组中非a血细胞的百分比,不应超过30%;测定A1B红细胞中非b血细胞的百分比,不应超过10%。
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