[Serotonin uptake of thrombocytes as a measure of thrombogenicity of adsorbents].

Zeitschrift fur Urologie und Nephrologie Pub Date : 1990-10-01

U Frick, K U Möritz, I Wiedenhöft, G Frick, G Kraatz

引用次数: 0

Abstract

Serotonin intake into platelets is an active carrier-mediated metabolic achievement. This uptake may be reduced by unphysiological irritation on platelet membrane. Therefore, it is suitable for judgement of thrombogenicity of biomaterials. The 14C serotonin intake after blood contact with various adsorbents was investigated: Haemoresin (GDR), Adsorba 300 C (USSR) and syrendivinylbenzencopolymer FK 1621 (GDR). Only by the latter the serotonin intake was significantly reduced with 72.5 +/- 2.0% in comparison with siliconized glas (84.0 +/- 1.5%; p less than 0.001). Precision and analytical sensitivity of the method are high with a variation coefficient of 1.5 to 3.5%.

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[血小板的血清素摄取作为吸附剂致血栓性的一种测量方法]。

血清素进入血小板是一个活跃的载体介导的代谢成就。这种摄取可能因血小板膜的非生理性刺激而减少。因此，它适用于生物材料的致血栓性判断。研究了血液接触不同吸附剂后14C - 5 -羟色胺的摄入量:血液树脂(GDR)，吸附剂300c(苏联)和syrendi乙烯基苯聚合物FK 1621 (GDR)。与硅化玻璃(84.0 +/- 1.5%)相比，后者的血清素摄入量显著降低，为72.5 +/- 2.0%;P < 0.001)。该方法精密度高，分析灵敏度高，变异系数为1.5 ~ 3.5%。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Zeitschrift fur Urologie und Nephrologie

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