The validity of animal models in the search for drugs for the aging brain.

Drug design and delivery Pub Date : 1990-12-01
G Pepeu, I M Pepeu, F Casamenti
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Abstract

The search for drugs of use in the treatment of age-associated memory impairment, multi-infarct dementia, and Alzheimer's disease is frustrated by the expense or inadequacy of animal models of these conditions. We hope that this critical review of existing models will stimulate the use and proper interpretation of the best of these models, and encourage thinking in devising new models.

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动物模型在寻找抗脑衰老药物中的有效性。
寻找用于治疗与年龄相关的记忆障碍、多发性梗死性痴呆和阿尔茨海默病的药物,由于这些疾病的动物模型的费用或不足而受挫。我们希望这种对现有模型的批判性回顾将刺激对这些模型中最好的模型的使用和正确解释,并鼓励在设计新模型时进行思考。
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