Charge densities of atoms of conjugated styryl ketones having activity against L1210 leukemia cells.

Drug design and delivery Pub Date : 1990-12-01
J R Dimmock, E Erciyas, K K Sidhu, X Luo, P G Mezey, T M Allen, L Murray
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引用次数: 0

Abstract

Electron density calculations were undertaken on several atoms in a series of 3-substituted-4-phenyl-3-buten-2-ones in order to gain insight into the molecular features which affect charge densities. The results indicate that substituents at position 3 alter the electron densities of the olefinic group but have little effect on the acetyl function. The compounds were tested against L1210 cells in vitro, and the results suggest that electronic--but not steric--factors are important in affecting cytotoxicity. The most active compound was 3-phenylmethylene-2,4-pentanedione (1c) with an ED50 value of 1.06 x 10(-8) M.

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对L1210白血病细胞有活性的共轭苯乙烯酮原子的电荷密度。
为了深入了解影响电荷密度的分子特征,对一系列3-取代-4-苯基-3-丁烯-2- 1中的几个原子进行了电子密度计算。结果表明,3位取代基改变了烯烃基团的电子密度,但对乙酰基功能影响不大。这些化合物在体外对L1210细胞进行了测试,结果表明电子因子(而不是位阻因子)在影响细胞毒性方面很重要。活性最高的化合物为3-苯基亚甲基-2,4-戊二酮(1c), ED50值为1.06 × 10(-8) M。
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