More than a common acid buffering in the treatment of Non-Erosive GERD-like Clinical Spectrum: A Chios Masthia-based Formulation with (Cyto) Protecting Effect

R. Barreto, M. TODAi, Nikhil Kumar, K. Hayakawa, F. Marotta, Y. Imaoka, R. Catanzaro
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Abstract

The aim of this study was to test the clinical and mucosal benefit of a natural gastro-oesophageal mucosal protector DOGDG-121 in non-erosive GERD comprising from NERD, to Functional Heartburn and Hypersensitive oesophagus while also ascertain the symptom-free duration in patients with prior symptomatic relapsing GERD. 68 consecutive adult patients, reporting mild heartburn symptoms two or more days a week or at least moderate symptoms more than once a week for at least six months duration were prospectively recruited. Inclusion criteria were: recurrent typical GERD symptoms, such as heartburn and/or acid regurgitation and a duration of symptoms>6 months. Patients were divided in two groups comparable as for age, gender, BMI and pHmetry profile.
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在非糜烂性胃食管反流样临床谱治疗中,不仅仅是一种常见的酸缓冲剂:一种具有(细胞)保护作用的基于希俄斯·马西亚的制剂
本研究的目的是测试天然胃食管粘膜保护剂DOGDG-121在非糜烂性胃食管反流中的临床和粘膜益处,包括从NERD到功能性胃灼热和食道过敏,同时确定既往有症状复发的胃食管反流患者的无症状持续时间。本研究前瞻性招募了68名连续的成人患者,这些患者每周报告两天或两天以上的轻度胃灼热症状,或至少每周报告一次以上的中度胃灼热症状,持续时间至少为6个月。纳入标准为:复发性典型胃反流症状,如胃灼热和/或反酸,且症状持续时间>6个月。患者按年龄、性别、身体质量指数和体格特征分为两组。
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