Multifocal serous chorioretinitis in beagle dogs.

Lens and eye toxicity research Pub Date : 1990-01-01
F von Landenberg, U Biermann, H P Hamann, M Jacobs, A Metallinos
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Abstract

In the years 1988 and 1989, routine ophthalmological examinations of dogs from the company-owned beagle colony revealed a clinically inapparent chorioretinitis in 7.4 and 10% of the animals, respectively, as it has previously been described by Weisse et al. (1981). The alterations were seen mainly in the non-tapetal fundus, and they appeared more frequently in both eyes than in just one eye. Infection tests as well as virologic, bacteriologic and histopathologic investigations were performed in order to clarify the origin. A direct evidence of virus particles from processed ocular material by electron microscopy was not possible. Tests for growth on MDCK cells were negative. In bacteriologic tests, a gram positive, filiform, branched microorganism was isolated. The histopathologic findings in the subacute stage were a focal atrophy of the first retinal neuron and a focal proliferation of glia cells.

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比格犬多灶性浆液性脉络膜视网膜炎。
1988年和1989年,对该公司拥有的比格犬群的狗进行常规眼科检查,分别有7.4 %和10%的动物出现临床不明显的脉络膜视网膜炎,Weisse等人(1981)此前曾描述过这种情况。这种改变主要发生在非绒毡眼底,在双眼中出现的频率高于单眼。进行了感染试验以及病毒学、细菌学和组织病理学调查,以澄清起源。通过电子显微镜无法直接证明从处理过的眼部材料中存在病毒颗粒。MDCK细胞生长试验呈阴性。在细菌学试验中,分离出革兰氏阳性、丝状、支状微生物。亚急性期的组织病理学表现为第一个视网膜神经元的局灶性萎缩和神经胶质细胞的局灶性增殖。
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