[Effects of At-211 alpha irradiation on Ehrlich ascites tumor cells].

Eksperimental'naia onkologiia Pub Date : 1990-01-01
N L Shmakova, Iu V Norseev, A A Waĭnson, Z Siuch, T A Fadeeva, T E Fomenkova, V A Khalkin, A P Cherebatenko
{"title":"[Effects of At-211 alpha irradiation on Ehrlich ascites tumor cells].","authors":"N L Shmakova,&nbsp;Iu V Norseev,&nbsp;A A Waĭnson,&nbsp;Z Siuch,&nbsp;T A Fadeeva,&nbsp;T E Fomenkova,&nbsp;V A Khalkin,&nbsp;A P Cherebatenko","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The biological effect of 211At alpha-particles has been investigated using the Chinese hamster fibroblasts and Ehrlich carcinoma cells growth in vitro. The mean energy of 211At alpha-particles is 6.8 MeV, LET in tissue is 70-160 keV/microns; the half-life period of decomposition of 211At is 7.2 h. The end-points used were a decrease in the mitotic activity, an elevation of the number of degenerating cells, cell with chromosome aberrations and the cell survival. The RBE of alpha-particles in comparison with 60Co gamma-rays is close to 3.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 3","pages":"58-60"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eksperimental'naia onkologiia","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

The biological effect of 211At alpha-particles has been investigated using the Chinese hamster fibroblasts and Ehrlich carcinoma cells growth in vitro. The mean energy of 211At alpha-particles is 6.8 MeV, LET in tissue is 70-160 keV/microns; the half-life period of decomposition of 211At is 7.2 h. The end-points used were a decrease in the mitotic activity, an elevation of the number of degenerating cells, cell with chromosome aberrations and the cell survival. The RBE of alpha-particles in comparison with 60Co gamma-rays is close to 3.

分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
[At-211 α辐照对埃利希腹水肿瘤细胞的影响]。
利用中国仓鼠成纤维细胞和体外培养的埃利希癌细胞,研究了2111at α粒子的生物学效应。211At α粒子的平均能量为6.8 MeV,组织中的LET为70-160 keV/微米;211At的分解半衰期为7.2 h。终点为有丝分裂活性降低、退化细胞数量增加、染色体畸变细胞数量增加和细胞存活率增加。α粒子与60Co射线的RBE接近于3。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
"Experimental oncology": achievements and prospects for the future. Poly-drug cancer therapy based on ceramide. Venous thromboembolism in oncology. Identification of a novel binding partners for tumor suppressor PTEN by a yeast two-hybrid approach. Effect of 2'-deoxyisoguanosine on the growth of human tumor and normal cell lines.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1