Blood Group ABO, Placental Malaria Parasitization and Pregnancy Outcome in Munuki Primary health Centre in South Sudan

Abstract

Several studies in Malaria endemic areas have reported conflicting observations on Blood Group ABO association with placental Malaria and pregnancy outcome. The purpose of this study is to determine the association between Placental Malaria and Blood Group O in the Munuki Primary Health Care Centre in South Sudan. Material and Methods: This was a prospective study. Each pregnant lady was enrolled after signing of informed consent and meeting study entry criteria. In all 589 pregnant women were evaluated. For each done were; ABO phenotype ones, at the enrolment and testing for malaria in and twice in the cause of pregnancy. Peripheral blood malaria parasites testing were by using RDT test to describe the type of plasmodium species. Results: The 589 enrolled were as follows; 154 (32.6%), 124 (26.3%) and 182 (38.6%) primigravidae, secundigravidae and multigravidae, respectively. The ABO distribution was; 124 (A), 59 (B), 14 (AB) and 257 (O). Negative peripheral Malaria parasites for pregnant women at ANC have higher positive Peripheral Malaria at DR with OR 2.93 CI (1.78__4.88) and ANC positive Malaria cases had higher chances of become positive during delivery OR 0.43 CI (0.30___0.62). Blood group O and peripheral malaria at DR with OR 1.17 CI (0.92___1.48) and Other Blood group at DR with OR 0.84 CI (0.67___1.06). Blood group O participants had higher P. Falciparum 60 /106 accounts for 56.6%. These results revealed significance interaction effect of Placental Malaria Parasites in Blood group O in Munuki Primary Health Center in Juba-South Sudan. This study recommends usage of protective measures against malaria during pregnancy.