Design of radiosensitive gels and phantoms for irradiation assessment using MRI measurement: case of glottic cancer

Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136) Pub Date : 1997-10-30 DOI:10.1109/IEMBS.1997.757648

I. Rousselle, J. Rousseau, B. Castelain, T. Sarrazin, X. Marchandise, D. Gibon

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引用次数: 2

Abstract

Chemical dosimetry is a technique allowing tridimensional assessment of dose in radiotherapy. Magnetic resonance imaging provides 3D dose mapping of irradiated gels. Those gels are composed of an aqueous gel matrix containing radiosensitive compounds such as ferrous ions that are radio-oxidized or vinyl monomers that polymerize. There are specific requirements about soft-tissue equivalence that don't necessarily matched with MRI requirements, The differences between the parameters defining soft-tissue equivalence for the different gels are small enough to choose a gel not considering its tissue equivalence but considering its MRI T/sub 1/ or T/sub 2/ sensitivities, its linearity vs dose, etc. An important parameter to consider is the phantom morphology. Use of radiosensitive gels is interesting to simulate the irradiation of a part of the body with tissue/air interfaces and to study the 3D dose mapping in the case of a glottic tumor for example. Thus, it will be much easier to make that phantom if the gel is not oxygen sensitive.

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核磁共振成像测量辐照评估用放射敏感凝胶和显像的设计:声门癌一例

化学剂量学是一种可以对放射治疗中的剂量进行三维评估的技术。磁共振成像提供辐照凝胶的三维剂量图。这些凝胶由含水凝胶基质组成，其中含有放射性敏感化合物，如放射性氧化的铁离子或聚合的乙烯基单体。不同凝胶定义软组织等效性的参数之间的差异足够小，因此选择凝胶时不考虑其组织等效性，而是考虑其MRI T/sub 1/或T/sub 2/灵敏度，其线性度与剂量等。要考虑的一个重要参数是模体形态。使用放射敏感凝胶来模拟人体部分组织/空气界面的辐照和研究声门肿瘤的3D剂量映射是很有趣的。因此，如果凝胶对氧不敏感，就更容易制造出这种幻影。

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Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)

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