Drug release from glutaraldehyde-treated fibrin gels.

Drug design and delivery Pub Date : 1990-12-01
H O Ho, M T Sheu, T D Sokoloski, C Y Chen
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引用次数: 0

Abstract

Glutaraldehyde treatment of dexamethasone-containing cylindrical fibrin gels (obtained by the thrombin-induced polymerization of fibrinogen in the presence of the drug) causes cross-linking of the gels and modification of the pore structure. The effect on the release of dexamethasone was assessed by measuring the diffusion coefficient of the drug across treated and untreated gels; diffusion across the treated gels was significantly decreased as compared with untreated gels, but was little affected by the concentration of glutaraldehyde used in the treatment. In biodegradable tests, the treated gels (all concentrations of glutaraldehyde) were resistant to digestion even in the presence of plasmin, but untreated gels were digested, and the digestion rate was accelerated by plasmin. The volume of the gels was progressively reduced as the concentration of glutaraldehyde was increased or the amount of fibrinogen was decreased, but the extent of the reduction did not correlate with the changes in the diffusion coefficient.

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戊二醛处理纤维蛋白凝胶的药物释放。
戊二醛处理含地塞米松的圆柱形纤维蛋白凝胶(在药物存在下由凝血酶诱导的纤维蛋白原聚合得到)引起凝胶的交联和孔结构的修饰。通过测定药物在处理和未处理凝胶中的扩散系数来评估药物对地塞米松释放的影响;与未处理的凝胶相比,处理凝胶的扩散明显减少,但受处理中使用的戊二醛浓度的影响很小。在可生物降解试验中,处理过的凝胶(所有浓度的戊二醛)即使在存在纤溶酶的情况下也不耐消化,但未处理的凝胶可以消化,并且纤溶酶加速了消化速度。随着戊二醛浓度的增加或纤维蛋白原含量的减少,凝胶的体积逐渐减小,但减小的程度与扩散系数的变化无关。
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