Relation of alpha and gamma interferon levels to development of AIDS in homosexual men.

Journal of Experimental Pathology Pub Date : 1990-01-01
C R Rinaldo, J A Armstrong, L A Kingsley, S Zhou, M Ho
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Abstract

Homosexual men who were human immunodeficiency virus (HIV) seropositive at enrollment into the Pittsburgh portion of the Multicenter AIDS Cohort Study had elevated titers of serum alpha and gamma interferon (IFN) within 24 months prior to development of AIDS. In contrast, subjects who developed AIDS relatively early after seroconversion to HIV during this study did not have increased levels of alpha or gamma IFN.

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α和γ干扰素水平与男同性恋者艾滋病发展的关系。
在多中心艾滋病队列研究的匹兹堡部分入组时,人类免疫缺陷病毒(HIV)血清阳性的男同性恋者在发生艾滋病前24个月内血清α和γ干扰素(IFN)滴度升高。相比之下,在这项研究中,血清转化为HIV后相对较早发展为艾滋病的受试者,α或γ干扰素水平没有增加。
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