INFLUENCE OF THE IMMOBILIZATION ON STABILITY OF THE LYOPHILIZED BACTERIAL CULTURES

Abstract

The immobilization of the cages which are a part of pro-biotic medicines is directed to achievement of a number of the biological and technological effects increasing quality and, respectively, consumer proper-ties of products. The biological effect at different ap-plication of sorbents is caused by increase in re-sistance of a probiotic to action of bactericidal fac-tors of a GIT (gastric juice, bile). The positive techno-logical aspect of an immobilization is connected with achievement of more expressed resistance of cages to physical impacts: to freezing, thawing, drying and other manipulations with bacterial cultures during production. Besides the specified effects, at approba-tion of new sorbents their influence on persistence of specific activity of the immobilized cultures in the course of storage of medicines attracts interest that has the big practical importance for definition and a regulation of an expiration date of a probiotic. Ap-proved as the carrier гомогенат laminarias makes positive impact on stability of the lyophilized culture of bifidobacteria.