Process intensification platforms for application in bioengineering

M. Marques, P. Fernandes, Carla C. C. R. de Carvalho
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Abstract

The work presented reports the use of small scale reactors, with 15 mL-3 μL of volume, in bioprocesses. This field of research is of acknowledged relevance, since the rational use of small scale reactors is contributing to speed up process development in several areas of biotechnology, in particular due to the possibility of carrying out high throughput assays. Small scale reactors are available in different working volumes, configurations and architectures. These bioreactors are currently used in a wide array of applications, from cell screening to process optimization. The present work is focused on three major application areas, namely steroid biotransformations, siderophore production and screening of antibacterial agents. Results have shown the reliability of these platforms as suitable alternatives of traditional reactors and as screening tools. Fully automated platforms with monitoring and control devices are on the pipeline to further take advantage of the high throughput capability.
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生物工程应用的过程强化平台
这项工作报告了在生物过程中使用15 mL-3 μL体积的小型反应器。这一研究领域具有公认的相关性,因为合理使用小型反应器有助于加速若干生物技术领域的工艺发展,特别是因为有可能进行高通量分析。小型反应器有不同的工作体积、配置和结构。这些生物反应器目前用于广泛的应用,从细胞筛选到工艺优化。目前的工作主要集中在类固醇生物转化、铁载体的生产和抗菌药物的筛选三个主要应用领域。结果表明,这些平台作为传统反应器的合适替代品和筛选工具是可靠的。带有监测和控制设备的全自动平台正在筹备中,以进一步利用高通量能力。
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