Peter Kozuch MD , Magdalena Petryk MD , Andrew Evans MD , Howard W. Bruckner MD
{"title":"TREATMENT OF METASTATIC PANCREATIC ADENOCARCINOMA","authors":"Peter Kozuch MD , Magdalena Petryk MD , Andrew Evans MD , Howard W. Bruckner MD","doi":"10.1016/S0039-6109(05)70153-5","DOIUrl":null,"url":null,"abstract":"<div><div><span><span>Gemcitabine<span><span> is a promising agent for metastatic pancreatic cancer. Before gemcitabine, </span>survival time with metastatic disease averaged 3 to 5 months, and objective responses were few. Even when tumors underwent objective regression, questions about the degree of benefit and cost versus toxicity were raised. The consensus is, however, that </span></span>systemic treatment is warranted for most patients with </span>pancreatic adenocarcinoma. This article reviews single-agent and combination chemotherapy for metastatic pancreatic cancer.</div></div>","PeriodicalId":54441,"journal":{"name":"Surgical Clinics of North America","volume":"81 3","pages":"Pages 683-690"},"PeriodicalIF":2.8000,"publicationDate":"2001-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surgical Clinics of North America","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0039610905701535","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Gemcitabine is a promising agent for metastatic pancreatic cancer. Before gemcitabine, survival time with metastatic disease averaged 3 to 5 months, and objective responses were few. Even when tumors underwent objective regression, questions about the degree of benefit and cost versus toxicity were raised. The consensus is, however, that systemic treatment is warranted for most patients with pancreatic adenocarcinoma. This article reviews single-agent and combination chemotherapy for metastatic pancreatic cancer.
期刊介绍：
Surgical Clinics of North America has kept surgeons informed on the latest techniques from leading surgical centers worldwide. Each bimonthly issue (February, April, June, August, October, and December) is devoted to a single topic relevant to the busy surgeon, with articles written by experts in the field. Case studies and complete references are also included to give you the most thorough data you need to stay on top of your practice. Topics include general surgery, alimentary surgery, abdominal surgery, critical care surgery, trauma surgery, endocrine surgery, breast cancer surgery, transplantation, pediatric surgery, and vascular surgery.
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