Automated construction system for fine lattice shape structures based on alginate gel fiber

Abstract

Recently, several studies have reported, the in vitro fabrication of small scale 3D tissues. However, in large cell structures, oxygen and nutrients are not supplied to the inside of the tissue. In this case, cells at the center will die. We propose an automated system for the construction of a fine lattice shaped structure, based on hydrogel fiber to produce active 3D tissues in vitro. To evaluate the proposed system, a fine lattice structure was constructed as a basic experiment of 3D tissue form.