Yosuke Sawada, H. Hosokawa, Kiyoshi Matsumura, Shigeo Kobayashi
{"title":"Molecular Mechanism of Neuropathic Pain","authors":"Yosuke Sawada, H. Hosokawa, Kiyoshi Matsumura, Shigeo Kobayashi","doi":"10.1109/ICKS.2008.24","DOIUrl":null,"url":null,"abstract":"There are many patients suffering from neuropathic pain. Reactive oxygen species (ROS) is thought to be a mediator of neuropathic pain. In addition, neuropatic pain is aggravated by low temperature. However, receptor of ROS and low temperature is unknown. TRPA1 is activated by pain- producing agents such as allyl isothiocyanate or formaldehyde. We hypothesized that TRPA1 is receptor of ROS and low temperature on nociceptor. The purpose of present study is to investigate the validity of this hypothesis using Ca2+ imagining, patch clamp. Deep cooling (<17degC) and ROS activates TRPA1 expressing HEK293 cells. These results indicate that TRPA1 is receptor of ROS and low temperature.","PeriodicalId":443068,"journal":{"name":"International Conference on Informatics Education and Research for Knowledge-Circulating Society (icks 2008)","volume":"49 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2008-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Conference on Informatics Education and Research for Knowledge-Circulating Society (icks 2008)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1109/ICKS.2008.24","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14
Abstract
There are many patients suffering from neuropathic pain. Reactive oxygen species (ROS) is thought to be a mediator of neuropathic pain. In addition, neuropatic pain is aggravated by low temperature. However, receptor of ROS and low temperature is unknown. TRPA1 is activated by pain- producing agents such as allyl isothiocyanate or formaldehyde. We hypothesized that TRPA1 is receptor of ROS and low temperature on nociceptor. The purpose of present study is to investigate the validity of this hypothesis using Ca2+ imagining, patch clamp. Deep cooling (<17degC) and ROS activates TRPA1 expressing HEK293 cells. These results indicate that TRPA1 is receptor of ROS and low temperature.
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