A new hypothesis: inhibitory potentials of the gap-junctional intercellular communication play an important role in the tumorigenesis induced by biomaterials
Toshie Tsuchiya, Atsushi Takahara, Stuart L. Cooper, R. Nakaoka, H. Degawa, Akitada Nakamura
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Abstract
The authors propose a new hypothesis that the inhibitory potentials of intercellular communication play an important role in the tumorigenesis induced by various biomaterials. The authors' study showed that the tumor-promoting activities of biomaterials were caused by some additives, some catalysts, the leachable oligomers and the surface interaction of cells and materials.
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