Physiological modulation of alpha-adrenoceptor and 5HT receptor expression in blood vessels.

Blood vessels Pub Date : 1990-01-01 DOI:10.1159/000158805
J C McGrath, W R Dunn, A G Templeton
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引用次数: 9

Abstract

In vitro experiments on vascular smooth muscle often fail to reveal phenomena clearly demonstrable in vivo. Several recent observations in our laboratory have revealed the facility to uncover responses mediated by receptors whose functional expression had remained hidden with the standard experimental conditions first employed: conversely manipulation of conditions can selectively hide a particular receptor's response. Examples include the uncovering of responses to: 5HT1 receptors by raised O2 tension (via cyclooxygenase products) in human umbilical vessels; alpha 2-adrenoceptors in rabbit saphenous artery by angiotensin II and alpha 2-adrenoceptors in perfused rat tail by elevating tone with vasopressin. The powerful synergism of agonists which cannot on their own cause contraction, can lead to inaccurate interpretations of agonist-antagonist interactions. Finally, the influence of tissue metabolism on receptor expression clearly illustrates the complex processes which must be involved in vivo.

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血管中肾上腺素受体和5HT受体表达的生理调节。
血管平滑肌的体外实验往往不能揭示出在体内可以清楚证明的现象。我们实验室最近的几项观察显示,我们有能力揭示由受体介导的反应,这些受体的功能表达在最初采用的标准实验条件下一直是隐藏的:相反,条件的操纵可以选择性地隐藏特定受体的反应。例子包括:人类脐带血管中O2张力升高(通过环加氧酶产物)对5HT1受体的反应;血管紧张素II对兔大隐动脉的影响,血管紧张素II对大鼠尾的影响。激动剂的强大协同作用本身不能引起收缩,这可能导致对激动剂-拮抗剂相互作用的不准确解释。最后,组织代谢对受体表达的影响清楚地说明了必须在体内参与的复杂过程。
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