Peritonitis Related Death - A Retrospective Study Analysing Causative Factors In Chronic Peritoneal Dialysis

Abstract

Peritunitis is a well-known cause of mortality in perituneal dialysis (PD) patients. This retrospective analysis was first ever done in India, on a total of 127 patients, to disclose the clinical spectrum and risk profile of peritonitis-related mortality. A total of I 00 episodes of peritonitis occurred in 67 people who entered our cbronic perituneal dialysis (CPD) programme from Februsry 2005- March 2013. They were on peritoneal dialysis for 370 I patient-months. Twenty three patients (M8, F IS) died during an episode ofperitonitis(18.1l %). They have been on CPD forameanof29.25±21.98 (range 3 to 132) months, 77 of them were diabetic, 83 hypertensive. Fifty seven percent of those who died were hypertensive (P=0.045). Twenty nine patients had catheter removal for peritonitis which was done between 7-10 days. Co-morbidities present in the 23 patients who had peritonitis related were: diabetes mellitus (IS), hypertension (13), cardiovascular disease (5), Myasthenia Gravis (I). Culture negative peritonitis occurred in 39 episodes. The most common organism isolated were E.coli 7, Mycobacterium tuberculosis 5, Candida species 5. Advanced age, diabetes mellitus and hypertension, left ventricular dysfunction are factors which predisposed to mortality in our patients with peritonitis.