The Wellcome Foundation/World Health Organisation Onchocerciasis Chemotherapy Project Joint Programme to discover and develop a macrofilaricide for onchocerciasis.

Abstract

The primary objective of the Wellcome Foundation/World Health Organisation Onchocerciasis Chemotherapy Project, which began in July 1982, was the discovery and development of a safe and effective macrofilaricide for the treatment of onchocerciasis in man. A multidisciplinary Team of biologists, biochemists and medicinal chemists was assembled. They investigated a variety of potential targets in filariae and carried out in-depth lead optimisation studies on a number of different chemical series. A valuable contribution was made to our understanding of filarial biology and biochemistry and the susceptibility of filariae to various metabolic inhibitors. However, the ultimate goal of identification of a compound worthy of evaluation in man was not achieved and the programme was closed at the end of June 1989. Factors that contributed to this situation and some overall conclusions are discussed.