{"title":"Severe Transaminitis and Iron Deposition Induced by Anorexia Nervosa","authors":"Wilson Lee, Raymond E. Kim","doi":"10.33425/2639-9334.1048","DOIUrl":null,"url":null,"abstract":"Introduction: Anorexia nervosa is associated with a vast amount of general medical complications caused by severe weight loss and malnutrition. Common complications from affected organ systems lead to many physiologic disturbances and multi-organ complications, but rarely severe transaminitis or iron deposition. We discuss a case report of severe transaminitis and iron deposition in a patient with anorexia nervosa. Case: 31 year old male presents to the ED with a history of altered mental status and found to have severe transaminitis. Introduction of nutrition lead to a quick downtrend in liver transaminases with eventual normalization. Additionally, iron deposition as seen in the liver of our patient. Discussion: Severely elevated transaminitis has been a rare complication of anorexia nervosa. Starvation induced autophagy has been a proposed mechanism. There has been one case report of hepatic iron deposition in a patient with anorexia nervosa. Iron deposition has been seen in starved mice livers with gluconeogenesis and alteration in iron homeostasis possibly playing a role.","PeriodicalId":211573,"journal":{"name":"Gastroenterology, Hepatology & Digestive Disorders","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gastroenterology, Hepatology & Digestive Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33425/2639-9334.1048","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: Anorexia nervosa is associated with a vast amount of general medical complications caused by severe weight loss and malnutrition. Common complications from affected organ systems lead to many physiologic disturbances and multi-organ complications, but rarely severe transaminitis or iron deposition. We discuss a case report of severe transaminitis and iron deposition in a patient with anorexia nervosa. Case: 31 year old male presents to the ED with a history of altered mental status and found to have severe transaminitis. Introduction of nutrition lead to a quick downtrend in liver transaminases with eventual normalization. Additionally, iron deposition as seen in the liver of our patient. Discussion: Severely elevated transaminitis has been a rare complication of anorexia nervosa. Starvation induced autophagy has been a proposed mechanism. There has been one case report of hepatic iron deposition in a patient with anorexia nervosa. Iron deposition has been seen in starved mice livers with gluconeogenesis and alteration in iron homeostasis possibly playing a role.