Assessment of Diastolic Myocardial Function in Neonates with Patent Ductus Arteriosus by Tissue Doppler Imaging

Abstract

Background : PDA connects aorta and pulmonary artery during intrafetal life and allows intrauterine blood fl ow from right side to left side. It is common to stay patent after birth especially in preterm. Study purpose : To correlate the effect of PDA hemodynamic signi fi cance on diastolic myocardial functions using tissue doppler. Methods : This study was conducted on 50 babies delivered in or admitted to Bab-Sheria Hospital University hospital categorized into three groups: Control, Patent ductus arteriosus cases with hemodynamic signi fi cance (HD-Sig. PDA) and PDA cases with no hemodynamic signi fi cance (NHSPDA). Results : There was higher (statistically signi fi cant) LA/AO ratio and lower (E/A) ratio in HD-Sig. PDA in comparison to NHSPDA and control group. There was statistically signi fi cant lower septal E ’ velocity and lower lateral wall E ’ velocity in both HD-Sig PDA and NHSPDA cases compared to the control group. There was lower mean values of both septal E ’ and lateral wall E ‘ in HD-Sig. PDA compared to NHSPDA. Conclusion : Neonates with HD-Sig. PDA have lower diastolic left ventricular velocities indicating relative degrees of left ventricular diastolic dysfunction compared to NHSPDA cases and control group. Tissue Doppler echocardiography is highly sensitive and non invasive procedure to evaluate diastolic myocardial functions in PDA cases.