Patterns of internal elastic lamina morphology in the canine common carotid artery.

Blood vessels Pub Date : 1990-01-01 DOI:10.1159/000158791
K J Hutchison, E J Sanders
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引用次数: 5

Abstract

The internal elastic lamina (IEL) of normal canine carotid arteries was examined by scanning electron microscopy in pressure-fixed specimens with intact endothelium. IEL appearance showed a marked variation between animals and was classified into fenestrated sheet, fibrous, and mixed varieties. This interpretation of the apparent morphology was confirmed with transmission electron microscopy. It was clear that IEL fenestrae were associated with surface depressions and that in areas of fibrous IEL there was surface elevation over individual fibres. Within individual animals there was little variation in the pattern of IEL either along or between common carotid arteries. If theories of atherogenesis involving the IEL are correct, the variation of IEL patterns between animals would suggest a corresponding variation of incidence and severity of atheromatous lesions of the common carotid artery between animals. Further, the occurrence of fibrous areas distributed throughout the fenestrated sheet would suggest a focal distribution of lesions along such arteries.

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犬颈总动脉内弹性板形态。
用扫描电镜对正常犬颈动脉内弹性层(IEL)进行了观察。IEL外观在动物间差异明显,可分为开孔片状、纤维状和混合型。透射电镜证实了这种对表面形貌的解释。很明显,IEL开窗与表面凹陷有关,在纤维性IEL区域,个别纤维表面升高。在单个动物中,沿颈总动脉或颈总动脉之间的IEL模式几乎没有变化。如果涉及IEL的动脉粥样硬化理论是正确的,动物之间IEL模式的差异将提示动物之间颈总动脉粥样硬化病变的发生率和严重程度的相应差异。此外,纤维区分布在整个开孔片的出现表明病变沿这些动脉有局灶性分布。
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