LENT Score as a Prognosis Factor for Overall Survival and Progression-Free Survival in Malignant Pleural Effusion Patients at Tertiary Hospitals in West Sumatera, Indonesia

Laisa Azka, Sabrina Ermayanti, Russilawati, Irvan Medison, Deddy Herman, Fenty Anggraininy
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Abstract

Background: Malignant pleural effusion (MPE) has a variable survival rate and prognosis. The LENT score is one method for assessing survival rates in patients with MPE. This study aimed to investigate the LENT score as a prognostic factor for overall survival (OS) and progression-free survival (PFS) of patients with MPE at a tertiary hospital in West Sumatera. Methods: This study was an observational analytic study involving several tertiary hospitals in West Sumatera with a minimum observation period of 2 years. Data were collected from medical records. We used Kaplan Meier analysis to assess OS and PFS. Results: A total of 198 subjects met the inclusion criteria. Most MPE patients in this study were aged ≥60 years, male, smokers, pleural fluid lactate dehydrogenase value <1500, ECOG 1, serum NLR value <9, and high-risk cancer, namely lung cancer. The distribution of LENT scores for MPE patients was evenly distributed among the low, medium, and high-risk groups. Kaplan Meier analysis showed that the median OS based on LENT scores were 804 days, 275 days, and 161 days, respectively (log-rank test p = 0.000). The median PFS based on LENT scores were 715 days, 202 days, and 106 days, respectively (log-rank test p=0.000). The OS and PFS findings are longer than previous studies. Conclusion: Based on LENT scores, overall survival and progression-free survival MPE patients at tertiary hospitals in West Sumatera have a better prognosis compared to previous studies.
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LENT评分作为印尼西苏门答腊三级医院恶性胸腔积液患者总生存期和无进展生存期的预后因素
背景:恶性胸腔积液(MPE)具有不同的生存率和预后。LENT评分是评估MPE患者生存率的一种方法。本研究旨在探讨在西苏门答腊的一家三级医院,LENT评分作为MPE患者总生存期(OS)和无进展生存期(PFS)的预后因素。方法:本研究采用观察性分析研究,涉及西苏门答腊多家三级医院,观察期最小为2年。数据是从医疗记录中收集的。我们采用Kaplan Meier分析评估OS和PFS。结果:198名受试者符合纳入标准。本研究中MPE患者多为年龄≥60岁、男性、吸烟者、胸膜液乳酸脱氢酶值<1500、ECOG值1、血清NLR值<9、高危癌症即肺癌。MPE患者的LENT评分在低、中、高危组中分布均匀。Kaplan Meier分析显示,基于LENT评分的中位OS分别为804天、275天和161天(log-rank检验p = 0.000)。基于LENT评分的中位PFS分别为715天、202天和106天(log-rank检验p=0.000)。OS和PFS的研究结果比以前的研究要长。结论:基于LENT评分,西苏门答腊三级医院的MPE患者的总生存期和无进展生存期与既往研究相比预后更好。
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