[Metoclopramide antagonizes dopamine-induced inhibition of lower esophageal sphincter pressure in the awake beagle].

Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR Pub Date : 1990-01-01

P Thies, H D Janisch, D H von Kleist, K U Wolf, K E Hampel

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Abstract

Different contradictory results, even in the same species of the DOP-effect on LESP have been reported. The aim of the present studies was to evaluate the effect of DOP on LES in purebread male beagles and whether in could be antagonised by the DOP-antagonist MCP. The LESP in beagles is sensitive to dopamine (DOP) and its "antagonist", metoclopramide (MCP). MCP raised the inhibited LESP after DOP-infusion in vivo, while it failed to change DOP-induced relaxation of opossum LES in vitro [1]. Data obtained after monotherapie with MCP did not exceed LESP-response to MCP after DOP-pretreatment. DOP applied as background counter-inhibition could be used to correct interdigestive phasic changements of LESP in order to reach a stable starting-point to investigate the action of LESP-stimulating compounds pharmacomanometrically. Due to DOP reflux-facilitating side effect via its decrease of LESP, large doses of DOP, as used in the intensiv care unit, should be administered together with sphincter-strengthening agents or antacid compounds.

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在清醒的小猎犬中，甲氧氯普胺可拮抗多巴胺诱导的食管下括约肌压力抑制。

即使在同一物种中，dopp对LESP的影响也有不同的相互矛盾的结果。本研究的目的是评价DOP对纯皮雄性比格犬LES的影响，以及DOP拮抗剂MCP是否能拮抗lep。比格犬的LESP对多巴胺(DOP)及其“拮抗剂”甲氧氯普胺(MCP)敏感。MCP在体内提高了dopo输注后被抑制的LESP，而在体外未能改变dopo诱导的负鼠LES松弛[1]。单药MCP治疗后获得的数据没有超过dopp预处理后对MCP的lesp反应。DOP作为背景抗抑制剂，可以纠正LESP的消化间期变化，为研究促LESP化合物的药物计量学作用提供一个稳定的起点。由于DOP通过降低LESP而促进返流的副作用，在重症监护病房使用的大剂量DOP应与括约肌强化剂或抗酸化合物一起使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gastroenterologisches Journal : Organ der Gesellschaft fur Gastroenterologie der DDR

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