Crypt cell population changes in the mouse jejunum during injury and repair after whole-body gamma irradiation.

Radiobiologia, radiotherapia Pub Date : 1990-01-01
K Nandchahal
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Abstract

Adult Swiss albino mice were exposed to 4.5 Gy, 9.0 Gy and 12.0 Gy of 60Co gamma rays and post-irradiation variations in the crypt cell population of jejunum were studied. In all the three exposure groups, a significant decrease in cellularity was observed on day 1. With the beginning of recovery crypt cell population tended to increase and gradually approached normal value by day 8 and 14 in mice exposed to 4.5 Gy and 9.0 Gy respectively. In mice exposed to 12.0 Gy normal value was never attained.

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全身伽玛照射后小鼠空肠损伤和修复过程中隐窝细胞群的变化。
研究了成年瑞士白化小鼠在4.5 Gy、9.0 Gy和12.0 Gy 60Co γ射线照射下空肠隐窝细胞群的变化。在所有三个暴露组中,在第1天观察到细胞数量显著减少。4.5 Gy和9.0 Gy照射小鼠随着恢复的开始,隐窝细胞数量逐渐增加,并在第8天和第14天逐渐接近正常值。暴露于12.0 Gy的小鼠从未达到正常值。
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