W. Wai Yew , S. Yuk Lin Kwan , W. Keung Ma , K. Sang Lui
{"title":"Minimal bactericidal and inhibitory concentrations of of loxacin on Mycobacterium fortuitum at pH 7 and 5: therapeutic implications","authors":"W. Wai Yew , S. Yuk Lin Kwan , W. Keung Ma , K. Sang Lui","doi":"10.1016/0041-3879(90)90077-L","DOIUrl":null,"url":null,"abstract":"<div><p><em>Mycobacterium fortuitum</em> infections of sternotomy wounds have been successfully treated with ofloxacin, a fluoroquinolone. We studied the MBCs and MICs <em>in vitro</em> of this antibiotic on the organism under neutral pH (7) and acidic pH (5) and found marked escalation of these values under the latter condition. This provides hints on the therapy of these infections under <em>in vivo</em> settings.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 3","pages":"Pages 205-208"},"PeriodicalIF":0.0000,"publicationDate":"1990-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90077-L","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tubercle","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/004138799090077L","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
Mycobacterium fortuitum infections of sternotomy wounds have been successfully treated with ofloxacin, a fluoroquinolone. We studied the MBCs and MICs in vitro of this antibiotic on the organism under neutral pH (7) and acidic pH (5) and found marked escalation of these values under the latter condition. This provides hints on the therapy of these infections under in vivo settings.
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