Impaired dilatation of cerebral arterioles in chronic hypertension.

Blood vessels Pub Date : 1990-01-01 DOI:10.1159/000158817
D D Heistad, W G Mayhan, P Coyle, G L Baumbach
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引用次数: 68

Abstract

Several mechanisms impair cerebral vasodilatation during chronic hypertension. First, the external diameter of cerebral arterioles is reduced during chronic hypertension by structural 'remodeling'. Thus, both vascular hypertrophy and remodeling result in encroachment on the lumen. Second, endothelium-dependent dilatation of cerebral vessels is impaired during chronic hypertension. Third, blood flow through cerebral collaterals is impaired by chronic hypertension, so that an important compensatory mechanism is compromised. Impaired vasodilator responses, together with limitation of increases in collateral blood flow, may predispose to cerebral ischemia and stroke during chronic hypertension.

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慢性高血压患者脑小动脉扩张受损。
几种机制损害慢性高血压期间脑血管舒张。首先,在慢性高血压期间,脑小动脉外径通过结构“重塑”而减小。因此,血管肥大和重构都导致管腔的侵犯。其次,慢性高血压期间脑血管内皮依赖性扩张受损。第三,慢性高血压损害了脑络的血流量,从而损害了一个重要的代偿机制。血管舒张反应受损,加上侧枝血流量增加受限,可能易导致慢性高血压患者脑缺血和脑卒中。
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