Decreased activity of the sodium-calcium exchanger in tail artery of stroke-prone spontaneously hypertensive rats.

Blood vessels Pub Date : 1990-01-01 DOI:10.1159/000158810
L E Thompson, G J Rinaldi, D F Bohr
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引用次数: 14

Abstract

The ability of the Na-Ca exchanger to modify vascular relaxation was studied in rings isolated from tail arteries of stroke-prone spontaneously hypertensive rats (SHRSP) and normotensive Wistar-Kyoto rats (WKY). The arteries were contracted with norepinephrine (NE) 1 microM and after stabilization they were transferred to a Ca-free physiological salt solution still in presence of NE. The time to 50% relaxation (T-50) in these conditions was significantly greater in SHRSP (78 +/- 7 s) than in WKY (50 +/- 7 s). When the calcium pump was stopped with vanadate (VAN), the Ca uptake by the sarcoplasmic reticulum with ryanodine (RY) and the Na-Ca exchanger with a Na-free PSS, the relaxation was slowed (T-50 increased to 198 +/- 16 s in SHRSP and to 162 +/- 14 s in WKY). Releasing the Na-Ca exchanger only (i.e. still with VAN and RY but with normal Na in the bath) the T-50 for relaxation in Ca-free PSS was, in WKY, nearly as fast as in control conditions (54 +/- 8 s). However, the Na-Ca exchanger in SHRSP was not so effective, and the T-50 for relaxation was slower than in control conditions (122 +/- 10 s). We conclude that the activity of the Na-Ca exchanger is depressed in tail arteries of SHRSP. This abnormality in resistance vessels, would contribute to the enhanced vascular tone present in hypertension.

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卒中易感自发性高血压大鼠尾动脉钠钙交换器活性降低。
在脑卒中易感自发性高血压大鼠(SHRSP)和正常Wistar-Kyoto大鼠(WKY)的尾动脉环中,研究了Na-Ca交换剂改变血管舒张的能力。用1微米的去甲肾上腺素(NE)收缩动脉,稳定后将其转移到仍有NE存在的无ca生理盐溶液中。在这些条件下,SHRSP (78 +/- 7 s)达到50%弛豫时间(T-50)明显大于WKY (50 +/- 7 s)。当钙泵用钒酸盐(VAN)停止,肌浆网用ryanodine (RY)和Na-Ca交换剂用无na PSS时,弛豫时间(T-50)增加到SHRSP的198 +/- 16 s, WKY的162 +/- 14 s)减慢。在无ca的PSS中,仅释放Na- ca交换剂(即仍有VAN和RY,但槽内Na正常),在WKY中,Na- ca交换剂的弛豫T-50几乎与对照组一样快(54 +/- 8 s),而在SHRSP中Na- ca交换剂的弛豫T-50则不如对照组有效(122 +/- 10 s)。我们得出结论,SHRSP尾动脉中Na- ca交换剂的活性被抑制。这种阻力血管的异常会导致高血压时血管张力的增强。
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