[Bone replacement using demineralized allogeneic bone in animal experiments].

N Schwarz, H Redl, G Schlag
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Abstract

The implantation of bone matrix in muscle bag or trepanation defects of rats with greatest reproducibility will induce osteogenesis and defect healing. The phenomenon of osteo-induction was possible to obtain only in first steps in higher developed mammals. Investigations in nude rats have shown a clear difference in biologic reaction on the matrix of various species. The osteo-regeneration in replacement weak defect of ulnar bone in dogs showed a massive greater reactivity of autogenous spongiosa, whereas bank spongiosa and bone matrix produced not more new bone as the control. An increase of osteoinductive matrix potency is a supposition for practical use in case of severe bone defects.

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[动物实验中使用脱矿异体骨进行骨置换]。
骨基质植入大鼠肌袋或钻孔缺损可诱导成骨和缺损愈合。在较发达的哺乳动物中,骨诱导现象仅在最初阶段才有可能获得。裸鼠实验表明,不同种类基质的生物反应有明显差异。在犬尺骨置换弱缺损的骨再生中,自体海绵的反应性显著增强,而对照的库海绵和骨基质产生的新骨量不明显。在严重骨缺损的情况下,骨诱导基质效力的增加是一种实际应用的假设。
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