Evaluation of the effectiveness of chronocorrection of hemocoagulation and microcirculation by angioprotectors and antiplatelet agents of diabetic microangiopathy

Abstract

The efficacies of four protocols for treating patients with insulin-dependent diabetes mellitus (IDDM) and microangiopathies of the I and II degree are compared: traditional therapy with pro dectin (250 mg) and trental (100 mg) 3 times daily (17 patients), prodectin (250 mg) and aspirin (125 mg) 3 times a day (16 patients), chronotherapy with prodectin in a dose of 250 mg and trental in a dose of 100 mg once a day (17 patients), and prodectin (250 mg) and aspirin (125 mg) once a day 1.5-2 h before the acrophase of the circadian rhythm of blood coagulation, microcirculation, and peripheral hemodynamics parameters (16 patients). Before and 15-17 days after treatment, blood coagulation values were studied by the autocoagulation and hemolysate aggregation tests, measurements of blood fibrinogen, antithrombin III, soluble fibrin monomer complexes, and fibrinolytic activity of the blood; microcirculation was assessed by biomicroscopy of the eye conjunctiva, and peripheral hemodynamics by the radioactive xenome method and rheova- sography of the shin. The studies demonstrated a higher efficacy of chronotherapy in comparison with traditional prodectin in combination with trental and aspirin.