[Transforming growth factor beta in the vitreous of patients with epiretinal proliferation].

A Gaudric, A Glacet-Bernard, G Clément, L Falquerho, D Barritault, G Coscas
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Abstract

Recent evidence suggests that TGF beta, a substance synthetized and released by Retinal Pigment Epithelial (RPE) cells, might play a role in fibrotic preretinal proliferation. We measured the concentration of this factor by radioreceptor assay in samples of vitreous obtained from 17 patients by vitrectomy. Seven had uncomplicated Retinal Detachment (RD) and 10 had either Proliferative Vitreoretinopathy (PVR) or Epimacular Membranes (EM). In the RD group, the mean concentration of TGF beta was 0.06 p mole/ml of vitreous, and in the PVR group, 0.21 p mole/ml. The total mitogenic activity of native vitreous and the amounts of a and b FGF in each sample were also measured, but were not different in the 2 groups. These results suggest that TGF beta is involved in the mechanism of excessive repair which characterises preretinal proliferation.

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[视网膜前增生患者玻璃体中转化生长因子β]。
最近有证据表明,由视网膜色素上皮细胞(RPE)合成并释放的TGF β可能在纤维化的视网膜前增殖中起作用。我们用放射受体测定法测定了17例玻璃体切除术患者玻璃体样本中该因子的浓度。7例为无并发症的视网膜脱离(RD), 10例为增生性玻璃体视网膜病变(PVR)或黄斑外膜(EM)。RD组玻璃体中TGF - β平均浓度为0.06 p摩尔/ml, PVR组为0.21 p摩尔/ml。测定各样品天然玻璃体的总有丝分裂活性及a、b FGF的含量,两组间差异无统计学意义。这些结果表明,TGF β参与了视网膜前增殖特征的过度修复机制。
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