Adrenocortical function in patients with pulmonary tuberculosis

G. Raghupati Sarma, Chandra Immanuel, Geetha Ramachandran, P.V. Krishnamurthy, V. Kumaraswami, R. Prabhakar
{"title":"Adrenocortical function in patients with pulmonary tuberculosis","authors":"G. Raghupati Sarma,&nbsp;Chandra Immanuel,&nbsp;Geetha Ramachandran,&nbsp;P.V. Krishnamurthy,&nbsp;V. Kumaraswami,&nbsp;R. Prabhakar","doi":"10.1016/0041-3879(90)90041-6","DOIUrl":null,"url":null,"abstract":"<div><p>Adrenocortical function was studied in patients with pulmonary tuberculosis and the findings compared with those in healthy subjects. Plasma cortisol levels in newly diagnosed patients were appreciably higher than in the healthy subjects (P&lt; 0.001). A normal (positive) response to ACTH (tetracosactrin) stimulation was observed in 35 (97%) of 36 healthy subjects, 15 (56%) of 27 newly diagnosed patients with tuberculosis and 5 (42%) of 12 chronic cases (i.e. those who had had the disease for more than 3 years); the difference between the healthy subjects and the two groups of tuberculosis patients was highly significant (P&lt;0.001). Dexamethasone caused an appreciable decrease in the plasma cortisol levels of tuberculosis patients. Considering the diurnal variation of cortisol secretion, there was a steady decline in the cortisol levels between 08:00 and 20:00 in the healthy subjects (P=0.02); in the tuberculosis patients, however, there was a decrease upto 16:00 followed by a significant increase (P=0.05), and the mean value at 20:00 was similar to that at 08:00.</p></div>","PeriodicalId":23472,"journal":{"name":"Tubercle","volume":"71 4","pages":"Pages 277-282"},"PeriodicalIF":0.0000,"publicationDate":"1990-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0041-3879(90)90041-6","citationCount":"42","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tubercle","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/0041387990900416","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 42

Abstract

Adrenocortical function was studied in patients with pulmonary tuberculosis and the findings compared with those in healthy subjects. Plasma cortisol levels in newly diagnosed patients were appreciably higher than in the healthy subjects (P< 0.001). A normal (positive) response to ACTH (tetracosactrin) stimulation was observed in 35 (97%) of 36 healthy subjects, 15 (56%) of 27 newly diagnosed patients with tuberculosis and 5 (42%) of 12 chronic cases (i.e. those who had had the disease for more than 3 years); the difference between the healthy subjects and the two groups of tuberculosis patients was highly significant (P<0.001). Dexamethasone caused an appreciable decrease in the plasma cortisol levels of tuberculosis patients. Considering the diurnal variation of cortisol secretion, there was a steady decline in the cortisol levels between 08:00 and 20:00 in the healthy subjects (P=0.02); in the tuberculosis patients, however, there was a decrease upto 16:00 followed by a significant increase (P=0.05), and the mean value at 20:00 was similar to that at 08:00.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
肺结核患者的肾上腺皮质功能
对肺结核患者的肾上腺皮质功能进行了研究,并与正常人进行了比较。新诊断患者的血浆皮质醇水平明显高于健康受试者(P<0.001)。36名健康受试者中有35人(97%)、27名新诊断的结核病患者中有15人(56%)、12名慢性病例(即患病3年以上的患者)中有5人(42%)对ACTH(四sacactrin)刺激反应正常(阳性);健康受试者与两组结核病患者之间的差异非常显著(P<0.001)。地塞米松引起结核病患者血浆皮质醇水平明显下降。考虑到皮质醇分泌的日变化,健康受试者的皮质醇水平在08:00 - 20:00之间稳步下降(P=0.02);结核病患者在16:00前呈下降趋势,随后又显著上升(P=0.05), 20:00时的平均值与08:00时相似。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
自引率
0.00%
发文量
0
期刊最新文献
Smear-negative pulmonary tuberculosis. Volume contents Mobilising the appropriate T-cell subset: the immune response as taxonomist? Severe skin reactions to thiacetazone in East Nepal Koch's phenomenon: can it be corrected?
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1